Status: Closed
Activation Date: 1994JUL07
Closing Date: 2001APR30
Phase: III
Description: A Phase III Prospective Randomized Study of Adjuvant Chemotherapy with Vinorelbine and Cisplatin in Completely Resected Non-Small Cell Lung Cancer with Companion Tumour Marker Evaluation
Primary Publication Show
Year: 2005
Title: Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
Authors: Winton T;Livingston R;Johnson D;Rigas J;Johnston M;Butts C;Cormier Y;Goss G;Inculet R;Vallieres E;Fry W;Bethume D;Ayoub J;Ding K;Seymour L;Graham B;Tsao M;Gandara D;Kesler K;Demmy T;Shepherd F;
Reference: New England Journal of Medicine 2005 Jun 23; 352 (25)
Link: http://content.nejm.org/cgi/content/abstract/352/25/2589
Title: Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
Authors: Winton T;Livingston R;Johnson D;Rigas J;Johnston M;Butts C;Cormier Y;Goss G;Inculet R;Vallieres E;Fry W;Bethume D;Ayoub J;Ding K;Seymour L;Graham B;Tsao M;Gandara D;Kesler K;Demmy T;Shepherd F;
Reference: New England Journal of Medicine 2005 Jun 23; 352 (25)
Link: http://content.nejm.org/cgi/content/abstract/352/25/2589
Other Publications Show
Year: 2005
Title: Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
Authors: Winton T;Livingston R;Johnson D;Rigas J;Johnston M;Butts C;Cormier Y;Goss G;Inculet R;Vallieres E;Fry W;Bethume D;Ayoub J;Ding K;Seymour L;Graham B;Tsao M;Gandara D;Kesler K;Demmy T;Shepherd F;
Reference: New England Journal of Medicine 2005 Jun 23; 352 (25)
Link: http://content.nejm.org/cgi/content/abstract/352/25/2589
Year: 2006
Title: Class III beta tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: Analysis of the National Cancer Institute of Canada Clinical Trials Group study JBR.10
Authors: Reiman T;Lai R;Ding K;Winton T;Butts C;Mackey J;Dabbagh L;Seymour L;Tsao M;Shepherd F;Seve P;
Reference: Journal of Clinical Oncology 2006 Jun 2 ; 24 (18s Part 1, abstr 7051)
Link: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=40&abstractID=31077
Year: 2007
Title: Class III ?-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: Analysis of NCIC JBR.10
Authors: Seve P;Lai R;Ding K;Winton T;Butts C;Mackey J;Dumontet C;Dabbagh L;Aviel-Ronen S;Seymour L;Whitehead M;Tsao M;Shepherd FA;Reiman T;
Reference: Clinical Cancer Research 2007 Feb 1 ; 13 (3)
Link:
Year: 2007
Title: P53 protein over-expression but not p53 gene mutation is a poor prognostic marker and a predictive marker for survival benefit from adjuvant chemotherapy in non-small cell lung cancer in the JBR.10 trial
Authors: Tsao MS;Aviel-Ronen S;Ding K;Lau D;Liu N;Whitehead M;Seymour L;Winton T;Shepherd FA;
Reference: Journal of Clinical Oncology 2007 Jun 1 ; 25 (18s Part 1, abstr 7577)
Link: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=47&abstractID=31370
Year: 2007
Title: Gene expression prognostic classifiers for early stage non-small cell lung cancer
Authors: Tsao MS;Lau S;Boutros P;Pintilie M;Zhu C;Strumpf D;Penn L;Jurisica I;Shepherd FA;
Reference: Making Connections: A Canadian Cancer Research Conference Celebrating NCIC's 60th Anniversary 2007 Nov 15; (abstr ED-44)
Link:
Year: 2007
Title: Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non-small-cell lung cancer
Authors: Tsao M;Aviel-Ronen S;Ding K;Lau D;Liu N;Sakurada A;Whitehead M;Zhu C;Livingston R;Johnson DH;Rigas J;Seymour L;Winton T;Shepherd FA;
Reference: Journal of Clinical Oncology 2007 Nov 20; 25 (33)
Link:
Year: 2008
Title: Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
Authors: Shedden K;Taylor JMG;Enkemann SA;Tsao M;Yeatman TJ;Gerald WL;Eschrich S;Jurisica I;Giordano TJ;Misek DE;Chang AC;Zhu CQ;Strumpf D;Hanash S;Shepherd FA;Ding K;Seymour L;Naoki K;Pennell N;Weir B;Verhaak R;Ladd-Acosta C;Golub T;Gruidl M;Sharma A;Szoke J;Zakowski M;Rusch V;Kris M;Viale A;Motoi N;Travis W;Conley B;Seshan VE;Meyerson M;Kuick R;Dobbin KK;Lively T;Jacobson JW;Beer DG;
Reference: Nature Medicine 2008 Aug ; 14 (8)
Link: http://www.nature.com/nm/journal/v14/n8/abs/nm.1790.html
Year: 2008
Title: Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group
Authors: Pignon J;Tribodet H;Scagliotti GV;Douillard J;Shepherd FA;Stephens RJ;Dunant A;Torri V;Rosell R;Seymour L;Spiro SG;Rolland E;Fossati R;Aubert D;Ding K;Waller D;LeChevalier T;
Reference: Journal of Clinical Oncology 2008 Jul 20; 26 (21)
Link: http://www.jco.ascopubs.org/content/26/21/3552.abstract
Year: 2008
Title: Prognostic value of class III b-tubulin in operable non-small cell lung cancer and predictive value for adjuvant cisplatin-based chemotherapy: A validation study on three randomized trials
Authors: Reiman T;Seve P;Vataire A;Dunant A;Rosell R;Graziano S;Seymour L;Pirker R;Lai R;
Reference: Journal of Clinical Oncology 2008 May 30; 26 (15s Part I, abstr 7506)
Link: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=31961
Year: 2008
Title: A 15-gene expression signature prognostic for survival and predictive for adjuvant chemotherapy benefit in JBR.10 patients
Authors: Tsao MS;Zhu C;Ding K;Strumpf D;Pintilie M;Meyerson M;Seymour L;Jurisica I;Shepherd FA;
Reference: Journal of Clinical Oncology 2008 May 30; 26 (15s Part I, abstr 7510)
Link: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=32591
Year: 2009
Title: P53 IHC protein expression and tumor size predict survival benefit from adjuvant chemotherapy in stage IB non small cell lung cancer patients
Authors: Ding K;Shepherd FA;Tsao MS;Le Maitre A;Seymour L;
Reference: BIT's 2nd Annual World Cancer Congress 2009 Jun 22; ( )
Link:
Year: 2009
Title: High resolution genomic analysis of NSCLC reveals regions of DNA copy number gain that may be predictive of benefit from adjuvant chemotherapy
Authors: Craddock KJ;Buys TPH;Zhu CQ;Strumpf D;Pintillie M;Ding K;Seymour L;Jurisica I;Shepherd FA;Lam WL;Tsao M;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr PD12.2.6)
Link:
Year: 2009
Title: Validation of the prognostic and predictive value of class III beta tubulin for adjuvant chemotherapy in completely resected non-small cell lung cancer: results from four randomized trials
Authors: Reiman T;Seve P;Veillard A;Soria J;Rosell R;Taron M;Graziano S;Kratzke R;Seymour L;Shepherd F;Pignon J;Lai R;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr A4.2)
Link:
Year: 2009
Title: Impact of EGFR tyrosine kinase domain mutations on adjuvant chemotherapy in early stage non-small cell lung cancer
Authors: Tsao M;Sakurada A;Aviel-Ronen S;Ding K;Liu N;Gandara DR;Johnson DH;Rigas JR;Seymour L;Shepherd FA;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr B9.6)
Link:
Year: 2009
Title: Pathologic determinants of survival for adjuvant treatment of stage IB non-small cell lung cancer: An analysis of the National Cancer Institute of Canada and Intergroup Study JBR.10
Authors: Strevel EL;Ding K;Seymour L;Tsao MS;Le Maitre A;Shepherd FA;Burkes RL;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr B4.6)
Link:
Year: 2010
Title: LACE-Bio: Cross-validation and pooled analyses of the putative prognostic/predictive biomarkers p27, p16 and cyclin E in IALT, ANITA, JBR10 and CALGB 9633
Authors: Pirker R;Rousseau V;Paris E;Tsao MS;Aviel-Ronen S;Taron M;Kratzke R;Brambilla E;Seymour L;Filipits M;
Reference: Chicago Multidisciplinary Symposium in Thoracic Oncology 2010 Dec 9 ; (abstr 6)
Link:
Year: 2010
Title: Bax expression as a predictive marker of survival benefit in non-small cell lung carcinoma treated by adjuvant cisplatin-based chemotherapy
Authors: Brambilla E;Bourredjem A;Lantuejoul S;Tsao MS;Pignon JP;Kratzke R;Stahel R;Douillard JY;Seymour L;Soria JC;
Reference: Chicago Multidisciplinary Symposium in Thoracic Oncology 2010 Dec 9 ; (abstr 8)
Link:
Year: 2010
Title: Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10
Authors: Butts CA;Ding K;Seymour L;Twumasi-Ankrah P;Graham B;Gandara D;Johnson DH;Kesler KA;Green M;Vincent M;Cormier Y;Goss G;Findlay B;Johnston M;Tsao M;Shepherd FA;
Reference: Journal of Clinical Oncology 2010 Jan 1 ; 28 (1)
Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799232/?report=abstract&tool=pmcentrez
Year: 2010
Title: Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer
Authors: Zhu C;Ding K;Strumpf D;Weir BA;Meyerson M;Pennell N;Thomas RK;Naoki K;Ladd-Acosta C;Liu N;Pintilie M;Der S;Seymour L;Jurisica I;Shepherd FA;Tsao M;
Reference: Journal of Clinical Oncology 2010 Oct 10; 28 (29)
Link: http://jco.ascopubs.org/content/28/29/4417.abstract?cmpid=jco_etoc_10October2010
Year: 2010
Title: LACE-Bio pooled analysis of the prognostic and predictive value of KRAS mutation in completely resected non-small cell lung
Authors: Tsao MS;Hainaut P;Bourredjem A;Janne PA;Pignon J;Douillard J;Soria J;Seymour L;Shepherd FA;
Reference: Annals of Oncology 2010 Oct 11; 21 (Suppl 8, abstr 156)
Link:
Year: 2011
Title: Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer
Authors: Tsao M;Sakurada A;Ding K;Aviel-Ronen S;Ludkovski O;Liu N;Le Maitre A;Gandara D;Johnson D;Rigas J;Seymour L;Shepherd FA;
Reference: Journal of Thoracic Oncology 2011 Jan 1 ; 6 (1)
Link: http://journals.lww.com/jto/Abstract/2011/01000/Prognostic_and_Predictive_Value_of_Epidermal.24.aspx
Year: 2011
Title: Evaluation of progression-free survival as a surrogate endpoint for overall survival when evaluating the effect of chemotherapy and radiotherapy in locally advanced lung cancer using data from four individual patient data meta-analyses
Authors: Mauguen A;Michiels S;Burdett S;Tierney JF;Sause W;Mandrekar SJ;Dahlberg SE;Shepherd FA;Parmar M;Perry MC;O'Brien M;Le Pechoux C;Pignon J;
Reference: Journal of Thoracic Oncology 2011 Jun 1 ; 6 (6 suppl 2, abstr O42.05)
Link:
Year: 2011
Title: A pooled exploratory analysis of the impact of tumor size and KRAS mutations on survival benefit from adjuvant platinum-based chemotherapy (ACT) in node negative (N0) non-small cell lung cancer (NSCLC)
Authors: Cuffe S;Graziano S;Bourredjem A;Pignon J;Ezzalfani M;Seymour L;Strevel E;Burkes R;Capelletti M;Janne PA;Tsao MN;Shepherd FA;
Reference: Journal of Thoracic Oncology 2011 Jun 1 ; 6 (6 suppl 2, abstr O42.01)
Link:
Year: 2011
Title: A pooled analysis to evaluate the prognosis and predictive value of EGFR mutation on survival in patients with KRAS wild-type lung adenocarcinoma
Authors: Soria J;Brambilla E;Le Teuff G;Tsao MS;Janne PA;Hainaut P;Taron M;Kratzke RA;Shepherd FA;Pignon J;
Reference: Journal of Thoracic Oncology 2011 Jun 1 ; 6 (6 suppl 2, abstr MO16.06)
Link:
Year: 2011
Title: Evaluation of disease-free survival as surrogate endpoint for overall survival using two individual patient data meta-analyses of adjuvant chemotherapy in operable non-small cell lung cancer
Authors: Michiels S;Mauguen A;Fisher D;Burdett S;Paulus R;Mandrekar SJ;Belani CP;Shepherd FA;Eisen T;Pang H;Collette L;Le Pechoux C;Pignon J;
Reference: Journal of Clinical Oncology 2011 Jun 3 ; 29 (suppl; abstr 7004)
Link: http://meetinglibrary.asco.org/content/83123-102
Year: 2011
Title: Impact of Biorepositories in Clinical Trials: The NCIC Clinical trials Group Experience
Authors: Shepherd L;Virk S;Zeltser F;Shepherd F;Tsao M;
Reference: Canadian Cancer Research Conference 2011 Nov 27; ( )
Link:
Year: 2012
Title: Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials
Authors: Reiman T;Lai R;Veillard AS;Paris E;Soria JC;Rosell R;Taron M;Graziano S;Kratzke R;Seymour L;Shepherd FA;Pignon JP;Seve P;for the LACE-Bio Group;
Reference: Annals of Oncology 2012 Jan ; 23 (1)
Link: http://annonc.oxfordjournals.org/content/23/1/86.abstract
Year: 2012
Title: A Pooled Exploratory Analysis of the Effect of Tumor Size and KRAS Mutations on Survival Benefit From Adjuvant Platinum-Based Chemotherapy in Node-Negative Non-Small Cell Lung Cancer
Authors: Cuffe S;Bourredjem A;Graziano S;Pignon JP;Domerg C;Ezzalfani M;Seymour L;Strevel E;Burkes R;Capelletti M;Janne PA;Tsao MS;Shepherd FA;
Reference: Journal of Thoracic Oncology 2012 Jun 1 ; 7 (6)
Link: http://journals.lww.com/jto/Fulltext/2012/06000/A_Pooled_Exploratory_Analysis_of_the_Effect_of.3.aspx
Year: 2012
Title: Prognostic and predictive effects of KRAS mutation subtype in completely resected non-small cell lung cancer (NSCLC): A LACE-bio study
Authors: Shepherd FA;Bourredjem A;Brambilla E;Domerg C;Douillard J;Filipits M;Graziano SL;Hainaut P;Janne PA;Le Chevalier T;Le Teuff G;Pignon J;Pirker R;Seymour L;Soria J;Taron M;Tsao MS;
Reference: Journal of Clinical Oncology 2012 Jun 1 ; 30 (suppl; abstr 7007)
Link: http://meetinglibrary.asco.org/content/93748-114
Year: 2012
Title: Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue
Authors: Fehringer G;Liu J;Pintilie M;Sykes J;Liu N;Cheng D;Chen Z;Seymour L;Der SD;Shepherd FA;Tsao M;Hung RJ;
Reference: Proceedings of the American Association for Cancer Research 2012 Mar 31; (abstr 4210)
Link: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=c0b6839b-6e34-473e-9e0d-e8cc7a9424c4&cKey=b3d6581f-853a-4289-a7d4-4396a033b530&mKey={2D8C569E-B72C-4E7D-AB3B-070BEC7EB280}
Year: 2013
Title: Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy
Authors: Shepherd FA;Domerg C;Hainaut P;Janne PA;Pignon JP;Graziano S;Douillard J;Brambilla E;Le Chevalier T;Seymour L;Bourredjem A;Le Teuff G;Pirker R;Filipits M;Rosell R;Kratzke R;Bandarchi B;Ma X;Capelletti M;Soria J;Tsao MS;
Reference: Journal of Clinical Oncology 2013 Jun 10; 31 (17)
Link: http://jco.ascopubs.org/content/31/17/2173.abstract?sid=8578b1eb-b0b2-450e-870f-8ea01f1c0fc4
Year: 2013
Title: ERCC1 Isoform Expression and DNA Repair in Non-Small-Cell Lung Cancer
Authors: Friboulet L;Olaussen KA;Pignon J;Shepherd FA;Tsao M;Graziano S;Kratzke R;Douillard J;Seymour L;Pirker R;Filipits M;Andre F;Solary E;Ponsonnailles F;Robin A;Stoclin A;Dorvault N;Commo F;Adam J;Vanhecke E;Saulnier P;Thomale J;Le Chevalier T;Dunant A;Rousseau V;Le Teuff G;Brambilla E;Soria J;
Reference: New England Journal of Medicine 2013 Mar 21; 368 (12)
Link: http://dx.doi.org/10.1056/NEJMoa1214271
Year: 2013
Title: Cross-validation analysis of the prognostic significance of mucin expression in patients with resected non-small cell lung cancer treated with adjuvant chemotherapy: Results from IALT, JBR.10 and ANITA
Authors: Graziano SL;Lacas B;Vollmer R;Kratzke R;Popper H;Filipits M;Seymour L;Shepherd FA;Rosell R;Veillard AS;Taron M;Pignon JP;
Reference: Lung Cancer 2013 Oct 15; 82 (1)
Link: http://www.sciencedirect.com/science/article/pii/S0169500213002729
Year: 2013
Title: Prognostic and predictive value of a new IASLC/ATS/ERS lung adenocarcinoma classification in a pooled analysis of four adjuvant chemotherapy trials: a LACE-Bio study
Authors: Brambilla EM;Marguet S;Le Teuff G;Lantuejoul S;Shepherd FA;Seymour L;Kratzke R;Graziano SL;Popper H;Pignon J;Rosell R;Douillard J;Le Chevalier T;Soria J;Tsao M;
Reference: IASLC World Conference on Lung Cancer 2013 Oct 29; ( )
Link:
Year: 2015
Title: Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection
Authors: Tsao MS;Marguet S;Le Teuff G;Lantuejoul S;Shepherd FA;Seymour L;Kratzke R;Graziano SL;Popper HH;Rosell R;Douillard JY;Le-Chevalier T;Pignon JP;Soria JC;Brambilla EM;
Reference: Journal of Clinical Oncology 2015 Oct 20; 33 (30)
Link: http://jco.ascopubs.org/content/early/2015/04/27/JCO.2014.58.8335.abstract
Year: 2017
Title: A Cost-Effectiveness Analysis of Using the JBR.10-Based 15-Gene Expression Signature to Guide Adjuvant Chemotherapy in Early Stage Non-Small-Cell Lung Cancer
Authors: Wong KM;Ding K;Li S;Bradbury P;Tsao MS;Der SD;Shepherd FA;Chung C;Ng R;Seymour L;Leighl NB;
Reference: Clinical Lung Cancer 2017 Jan ; 18 (1)
Link: http://www.sciencedirect.com/science/article/pii/S1525730416301498
Year: 2018
Title: Genome-wide copy number analyses of samples from LACE-Bio project identify novel prognostic and predictive markers in early stage non-small cell lung cancer
Authors: Rotolo F;Zhu CQ;Brambilla E;Graziano SL;Olaussen K;Le-Chevalier T;Pignon JP;Kratzke R;Soria JC;Shepherd FA;Seymour L;Michiels S;Tsao MS;
Reference: Translational Lung Cancer Research; Vol 7, No 3 (June 2018): Translational Lung Cancer Research (Lung Cancer Screening) 2018 Jun 1 ; 7 (3)
Link: http://tlcr.amegroups.com/article/view/21273
Year: 21 F
Title: Prognostic and predictive effect of KRAS gene copy number and mutation status in early stage non-small cell lung cancer patients
Authors: Fung AS;Karimi M;Michiels S;Seymour L;Brambilla E;Le-Chevalier T;Soria JC;Kratzke R;Graziano SL;Devarakonda S;Govindan R;Tsao MS;Shepherd FA;Collaborative Group obotL;
Reference: Translational Lung Cancer Research 21 Feb 1 ; 10 (2)
Link: https://tlcr.amegroups.com/article/view/49499
Title: Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
Authors: Winton T;Livingston R;Johnson D;Rigas J;Johnston M;Butts C;Cormier Y;Goss G;Inculet R;Vallieres E;Fry W;Bethume D;Ayoub J;Ding K;Seymour L;Graham B;Tsao M;Gandara D;Kesler K;Demmy T;Shepherd F;
Reference: New England Journal of Medicine 2005 Jun 23; 352 (25)
Link: http://content.nejm.org/cgi/content/abstract/352/25/2589
Year: 2006
Title: Class III beta tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: Analysis of the National Cancer Institute of Canada Clinical Trials Group study JBR.10
Authors: Reiman T;Lai R;Ding K;Winton T;Butts C;Mackey J;Dabbagh L;Seymour L;Tsao M;Shepherd F;Seve P;
Reference: Journal of Clinical Oncology 2006 Jun 2 ; 24 (18s Part 1, abstr 7051)
Link: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=40&abstractID=31077
Year: 2007
Title: Class III ?-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: Analysis of NCIC JBR.10
Authors: Seve P;Lai R;Ding K;Winton T;Butts C;Mackey J;Dumontet C;Dabbagh L;Aviel-Ronen S;Seymour L;Whitehead M;Tsao M;Shepherd FA;Reiman T;
Reference: Clinical Cancer Research 2007 Feb 1 ; 13 (3)
Link:
Year: 2007
Title: P53 protein over-expression but not p53 gene mutation is a poor prognostic marker and a predictive marker for survival benefit from adjuvant chemotherapy in non-small cell lung cancer in the JBR.10 trial
Authors: Tsao MS;Aviel-Ronen S;Ding K;Lau D;Liu N;Whitehead M;Seymour L;Winton T;Shepherd FA;
Reference: Journal of Clinical Oncology 2007 Jun 1 ; 25 (18s Part 1, abstr 7577)
Link: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=47&abstractID=31370
Year: 2007
Title: Gene expression prognostic classifiers for early stage non-small cell lung cancer
Authors: Tsao MS;Lau S;Boutros P;Pintilie M;Zhu C;Strumpf D;Penn L;Jurisica I;Shepherd FA;
Reference: Making Connections: A Canadian Cancer Research Conference Celebrating NCIC's 60th Anniversary 2007 Nov 15; (abstr ED-44)
Link:
Year: 2007
Title: Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non-small-cell lung cancer
Authors: Tsao M;Aviel-Ronen S;Ding K;Lau D;Liu N;Sakurada A;Whitehead M;Zhu C;Livingston R;Johnson DH;Rigas J;Seymour L;Winton T;Shepherd FA;
Reference: Journal of Clinical Oncology 2007 Nov 20; 25 (33)
Link:
Year: 2008
Title: Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
Authors: Shedden K;Taylor JMG;Enkemann SA;Tsao M;Yeatman TJ;Gerald WL;Eschrich S;Jurisica I;Giordano TJ;Misek DE;Chang AC;Zhu CQ;Strumpf D;Hanash S;Shepherd FA;Ding K;Seymour L;Naoki K;Pennell N;Weir B;Verhaak R;Ladd-Acosta C;Golub T;Gruidl M;Sharma A;Szoke J;Zakowski M;Rusch V;Kris M;Viale A;Motoi N;Travis W;Conley B;Seshan VE;Meyerson M;Kuick R;Dobbin KK;Lively T;Jacobson JW;Beer DG;
Reference: Nature Medicine 2008 Aug ; 14 (8)
Link: http://www.nature.com/nm/journal/v14/n8/abs/nm.1790.html
Year: 2008
Title: Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group
Authors: Pignon J;Tribodet H;Scagliotti GV;Douillard J;Shepherd FA;Stephens RJ;Dunant A;Torri V;Rosell R;Seymour L;Spiro SG;Rolland E;Fossati R;Aubert D;Ding K;Waller D;LeChevalier T;
Reference: Journal of Clinical Oncology 2008 Jul 20; 26 (21)
Link: http://www.jco.ascopubs.org/content/26/21/3552.abstract
Year: 2008
Title: Prognostic value of class III b-tubulin in operable non-small cell lung cancer and predictive value for adjuvant cisplatin-based chemotherapy: A validation study on three randomized trials
Authors: Reiman T;Seve P;Vataire A;Dunant A;Rosell R;Graziano S;Seymour L;Pirker R;Lai R;
Reference: Journal of Clinical Oncology 2008 May 30; 26 (15s Part I, abstr 7506)
Link: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=31961
Year: 2008
Title: A 15-gene expression signature prognostic for survival and predictive for adjuvant chemotherapy benefit in JBR.10 patients
Authors: Tsao MS;Zhu C;Ding K;Strumpf D;Pintilie M;Meyerson M;Seymour L;Jurisica I;Shepherd FA;
Reference: Journal of Clinical Oncology 2008 May 30; 26 (15s Part I, abstr 7510)
Link: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=32591
Year: 2009
Title: P53 IHC protein expression and tumor size predict survival benefit from adjuvant chemotherapy in stage IB non small cell lung cancer patients
Authors: Ding K;Shepherd FA;Tsao MS;Le Maitre A;Seymour L;
Reference: BIT's 2nd Annual World Cancer Congress 2009 Jun 22; ( )
Link:
Year: 2009
Title: High resolution genomic analysis of NSCLC reveals regions of DNA copy number gain that may be predictive of benefit from adjuvant chemotherapy
Authors: Craddock KJ;Buys TPH;Zhu CQ;Strumpf D;Pintillie M;Ding K;Seymour L;Jurisica I;Shepherd FA;Lam WL;Tsao M;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr PD12.2.6)
Link:
Year: 2009
Title: Validation of the prognostic and predictive value of class III beta tubulin for adjuvant chemotherapy in completely resected non-small cell lung cancer: results from four randomized trials
Authors: Reiman T;Seve P;Veillard A;Soria J;Rosell R;Taron M;Graziano S;Kratzke R;Seymour L;Shepherd F;Pignon J;Lai R;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr A4.2)
Link:
Year: 2009
Title: Impact of EGFR tyrosine kinase domain mutations on adjuvant chemotherapy in early stage non-small cell lung cancer
Authors: Tsao M;Sakurada A;Aviel-Ronen S;Ding K;Liu N;Gandara DR;Johnson DH;Rigas JR;Seymour L;Shepherd FA;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr B9.6)
Link:
Year: 2009
Title: Pathologic determinants of survival for adjuvant treatment of stage IB non-small cell lung cancer: An analysis of the National Cancer Institute of Canada and Intergroup Study JBR.10
Authors: Strevel EL;Ding K;Seymour L;Tsao MS;Le Maitre A;Shepherd FA;Burkes RL;
Reference: Journal of Thoracic Oncology 2009 Sep 1 ; 4 (9 suppl 1, abstr B4.6)
Link:
Year: 2010
Title: LACE-Bio: Cross-validation and pooled analyses of the putative prognostic/predictive biomarkers p27, p16 and cyclin E in IALT, ANITA, JBR10 and CALGB 9633
Authors: Pirker R;Rousseau V;Paris E;Tsao MS;Aviel-Ronen S;Taron M;Kratzke R;Brambilla E;Seymour L;Filipits M;
Reference: Chicago Multidisciplinary Symposium in Thoracic Oncology 2010 Dec 9 ; (abstr 6)
Link:
Year: 2010
Title: Bax expression as a predictive marker of survival benefit in non-small cell lung carcinoma treated by adjuvant cisplatin-based chemotherapy
Authors: Brambilla E;Bourredjem A;Lantuejoul S;Tsao MS;Pignon JP;Kratzke R;Stahel R;Douillard JY;Seymour L;Soria JC;
Reference: Chicago Multidisciplinary Symposium in Thoracic Oncology 2010 Dec 9 ; (abstr 8)
Link:
Year: 2010
Title: Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10
Authors: Butts CA;Ding K;Seymour L;Twumasi-Ankrah P;Graham B;Gandara D;Johnson DH;Kesler KA;Green M;Vincent M;Cormier Y;Goss G;Findlay B;Johnston M;Tsao M;Shepherd FA;
Reference: Journal of Clinical Oncology 2010 Jan 1 ; 28 (1)
Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799232/?report=abstract&tool=pmcentrez
Year: 2010
Title: Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer
Authors: Zhu C;Ding K;Strumpf D;Weir BA;Meyerson M;Pennell N;Thomas RK;Naoki K;Ladd-Acosta C;Liu N;Pintilie M;Der S;Seymour L;Jurisica I;Shepherd FA;Tsao M;
Reference: Journal of Clinical Oncology 2010 Oct 10; 28 (29)
Link: http://jco.ascopubs.org/content/28/29/4417.abstract?cmpid=jco_etoc_10October2010
Year: 2010
Title: LACE-Bio pooled analysis of the prognostic and predictive value of KRAS mutation in completely resected non-small cell lung
Authors: Tsao MS;Hainaut P;Bourredjem A;Janne PA;Pignon J;Douillard J;Soria J;Seymour L;Shepherd FA;
Reference: Annals of Oncology 2010 Oct 11; 21 (Suppl 8, abstr 156)
Link:
Year: 2011
Title: Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer
Authors: Tsao M;Sakurada A;Ding K;Aviel-Ronen S;Ludkovski O;Liu N;Le Maitre A;Gandara D;Johnson D;Rigas J;Seymour L;Shepherd FA;
Reference: Journal of Thoracic Oncology 2011 Jan 1 ; 6 (1)
Link: http://journals.lww.com/jto/Abstract/2011/01000/Prognostic_and_Predictive_Value_of_Epidermal.24.aspx
Year: 2011
Title: Evaluation of progression-free survival as a surrogate endpoint for overall survival when evaluating the effect of chemotherapy and radiotherapy in locally advanced lung cancer using data from four individual patient data meta-analyses
Authors: Mauguen A;Michiels S;Burdett S;Tierney JF;Sause W;Mandrekar SJ;Dahlberg SE;Shepherd FA;Parmar M;Perry MC;O'Brien M;Le Pechoux C;Pignon J;
Reference: Journal of Thoracic Oncology 2011 Jun 1 ; 6 (6 suppl 2, abstr O42.05)
Link:
Year: 2011
Title: A pooled exploratory analysis of the impact of tumor size and KRAS mutations on survival benefit from adjuvant platinum-based chemotherapy (ACT) in node negative (N0) non-small cell lung cancer (NSCLC)
Authors: Cuffe S;Graziano S;Bourredjem A;Pignon J;Ezzalfani M;Seymour L;Strevel E;Burkes R;Capelletti M;Janne PA;Tsao MN;Shepherd FA;
Reference: Journal of Thoracic Oncology 2011 Jun 1 ; 6 (6 suppl 2, abstr O42.01)
Link:
Year: 2011
Title: A pooled analysis to evaluate the prognosis and predictive value of EGFR mutation on survival in patients with KRAS wild-type lung adenocarcinoma
Authors: Soria J;Brambilla E;Le Teuff G;Tsao MS;Janne PA;Hainaut P;Taron M;Kratzke RA;Shepherd FA;Pignon J;
Reference: Journal of Thoracic Oncology 2011 Jun 1 ; 6 (6 suppl 2, abstr MO16.06)
Link:
Year: 2011
Title: Evaluation of disease-free survival as surrogate endpoint for overall survival using two individual patient data meta-analyses of adjuvant chemotherapy in operable non-small cell lung cancer
Authors: Michiels S;Mauguen A;Fisher D;Burdett S;Paulus R;Mandrekar SJ;Belani CP;Shepherd FA;Eisen T;Pang H;Collette L;Le Pechoux C;Pignon J;
Reference: Journal of Clinical Oncology 2011 Jun 3 ; 29 (suppl; abstr 7004)
Link: http://meetinglibrary.asco.org/content/83123-102
Year: 2011
Title: Impact of Biorepositories in Clinical Trials: The NCIC Clinical trials Group Experience
Authors: Shepherd L;Virk S;Zeltser F;Shepherd F;Tsao M;
Reference: Canadian Cancer Research Conference 2011 Nov 27; ( )
Link:
Year: 2012
Title: Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials
Authors: Reiman T;Lai R;Veillard AS;Paris E;Soria JC;Rosell R;Taron M;Graziano S;Kratzke R;Seymour L;Shepherd FA;Pignon JP;Seve P;for the LACE-Bio Group;
Reference: Annals of Oncology 2012 Jan ; 23 (1)
Link: http://annonc.oxfordjournals.org/content/23/1/86.abstract
Year: 2012
Title: A Pooled Exploratory Analysis of the Effect of Tumor Size and KRAS Mutations on Survival Benefit From Adjuvant Platinum-Based Chemotherapy in Node-Negative Non-Small Cell Lung Cancer
Authors: Cuffe S;Bourredjem A;Graziano S;Pignon JP;Domerg C;Ezzalfani M;Seymour L;Strevel E;Burkes R;Capelletti M;Janne PA;Tsao MS;Shepherd FA;
Reference: Journal of Thoracic Oncology 2012 Jun 1 ; 7 (6)
Link: http://journals.lww.com/jto/Fulltext/2012/06000/A_Pooled_Exploratory_Analysis_of_the_Effect_of.3.aspx
Year: 2012
Title: Prognostic and predictive effects of KRAS mutation subtype in completely resected non-small cell lung cancer (NSCLC): A LACE-bio study
Authors: Shepherd FA;Bourredjem A;Brambilla E;Domerg C;Douillard J;Filipits M;Graziano SL;Hainaut P;Janne PA;Le Chevalier T;Le Teuff G;Pignon J;Pirker R;Seymour L;Soria J;Taron M;Tsao MS;
Reference: Journal of Clinical Oncology 2012 Jun 1 ; 30 (suppl; abstr 7007)
Link: http://meetinglibrary.asco.org/content/93748-114
Year: 2012
Title: Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue
Authors: Fehringer G;Liu J;Pintilie M;Sykes J;Liu N;Cheng D;Chen Z;Seymour L;Der SD;Shepherd FA;Tsao M;Hung RJ;
Reference: Proceedings of the American Association for Cancer Research 2012 Mar 31; (abstr 4210)
Link: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=c0b6839b-6e34-473e-9e0d-e8cc7a9424c4&cKey=b3d6581f-853a-4289-a7d4-4396a033b530&mKey={2D8C569E-B72C-4E7D-AB3B-070BEC7EB280}
Year: 2013
Title: Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy
Authors: Shepherd FA;Domerg C;Hainaut P;Janne PA;Pignon JP;Graziano S;Douillard J;Brambilla E;Le Chevalier T;Seymour L;Bourredjem A;Le Teuff G;Pirker R;Filipits M;Rosell R;Kratzke R;Bandarchi B;Ma X;Capelletti M;Soria J;Tsao MS;
Reference: Journal of Clinical Oncology 2013 Jun 10; 31 (17)
Link: http://jco.ascopubs.org/content/31/17/2173.abstract?sid=8578b1eb-b0b2-450e-870f-8ea01f1c0fc4
Year: 2013
Title: ERCC1 Isoform Expression and DNA Repair in Non-Small-Cell Lung Cancer
Authors: Friboulet L;Olaussen KA;Pignon J;Shepherd FA;Tsao M;Graziano S;Kratzke R;Douillard J;Seymour L;Pirker R;Filipits M;Andre F;Solary E;Ponsonnailles F;Robin A;Stoclin A;Dorvault N;Commo F;Adam J;Vanhecke E;Saulnier P;Thomale J;Le Chevalier T;Dunant A;Rousseau V;Le Teuff G;Brambilla E;Soria J;
Reference: New England Journal of Medicine 2013 Mar 21; 368 (12)
Link: http://dx.doi.org/10.1056/NEJMoa1214271
Year: 2013
Title: Cross-validation analysis of the prognostic significance of mucin expression in patients with resected non-small cell lung cancer treated with adjuvant chemotherapy: Results from IALT, JBR.10 and ANITA
Authors: Graziano SL;Lacas B;Vollmer R;Kratzke R;Popper H;Filipits M;Seymour L;Shepherd FA;Rosell R;Veillard AS;Taron M;Pignon JP;
Reference: Lung Cancer 2013 Oct 15; 82 (1)
Link: http://www.sciencedirect.com/science/article/pii/S0169500213002729
Year: 2013
Title: Prognostic and predictive value of a new IASLC/ATS/ERS lung adenocarcinoma classification in a pooled analysis of four adjuvant chemotherapy trials: a LACE-Bio study
Authors: Brambilla EM;Marguet S;Le Teuff G;Lantuejoul S;Shepherd FA;Seymour L;Kratzke R;Graziano SL;Popper H;Pignon J;Rosell R;Douillard J;Le Chevalier T;Soria J;Tsao M;
Reference: IASLC World Conference on Lung Cancer 2013 Oct 29; ( )
Link:
Year: 2015
Title: Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection
Authors: Tsao MS;Marguet S;Le Teuff G;Lantuejoul S;Shepherd FA;Seymour L;Kratzke R;Graziano SL;Popper HH;Rosell R;Douillard JY;Le-Chevalier T;Pignon JP;Soria JC;Brambilla EM;
Reference: Journal of Clinical Oncology 2015 Oct 20; 33 (30)
Link: http://jco.ascopubs.org/content/early/2015/04/27/JCO.2014.58.8335.abstract
Year: 2017
Title: A Cost-Effectiveness Analysis of Using the JBR.10-Based 15-Gene Expression Signature to Guide Adjuvant Chemotherapy in Early Stage Non-Small-Cell Lung Cancer
Authors: Wong KM;Ding K;Li S;Bradbury P;Tsao MS;Der SD;Shepherd FA;Chung C;Ng R;Seymour L;Leighl NB;
Reference: Clinical Lung Cancer 2017 Jan ; 18 (1)
Link: http://www.sciencedirect.com/science/article/pii/S1525730416301498
Year: 2018
Title: Genome-wide copy number analyses of samples from LACE-Bio project identify novel prognostic and predictive markers in early stage non-small cell lung cancer
Authors: Rotolo F;Zhu CQ;Brambilla E;Graziano SL;Olaussen K;Le-Chevalier T;Pignon JP;Kratzke R;Soria JC;Shepherd FA;Seymour L;Michiels S;Tsao MS;
Reference: Translational Lung Cancer Research; Vol 7, No 3 (June 2018): Translational Lung Cancer Research (Lung Cancer Screening) 2018 Jun 1 ; 7 (3)
Link: http://tlcr.amegroups.com/article/view/21273
Year: 21 F
Title: Prognostic and predictive effect of KRAS gene copy number and mutation status in early stage non-small cell lung cancer patients
Authors: Fung AS;Karimi M;Michiels S;Seymour L;Brambilla E;Le-Chevalier T;Soria JC;Kratzke R;Graziano SL;Devarakonda S;Govindan R;Tsao MS;Shepherd FA;Collaborative Group obotL;
Reference: Translational Lung Cancer Research 21 Feb 1 ; 10 (2)
Link: https://tlcr.amegroups.com/article/view/49499
Inventory
Hide Tissue Samples
| Disease Site | Trial Code | Patients Accrued | Patients - Blocks | Patients - Slides | Patients - Blocks and/or Slides |
| LUNG | BR10 | 532 | 451 | 454 | 471 |
(Core size is 0.6 mm)
Hide
Fluid Samples| Disease Site | Trial Code | Patients Accrued | TMA Blocks | Patients on TMA Blocks |
| LUNG | BR10 | 532 | 3 | 331 |
| Disease Site | Trial Code | Patients Accrued | Patients - Whole Blood | Patients - Cellular Component of Blood | Patients - DNA extracted from Blood | Patients - RNA extracted from Blood | Patients - Plasma | Patients - Serum | Patients - Urine | Patients - Buccal |
| LUNG | BR10 | 532 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |