Canadian Cancer Trials Group - Tumour Bank
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MA25 Details
Status: Closed 
Activation Date: 2001NOV22
Closing Date: 2003JUN15
Phase: III 

Description: Randomized Trial of Post-Mastectomy Radiotherapy in Stage II Breast Cancer in Women With One to Three Positive Axillary nodes 

Eligibility: Women with histologically confirmed adenocarcinoma of the breast, with the primary tumour < 5 cm and 1-3 postive axillary nodes (pathologic T1-2, pathologic N1). Patients with apocrine, adenocystic, or squamous carcinomas or sarcomas of the breast or bilateral breast cancer are not eligible. 

Objective: To compare overall and disease-free survival in pre- and post-menopausal women with Stage II breast cancer and 1 ? 3 positive nodes treated with or without radiation therapy following mastectomy and adjuvant chemotherapy. To assess local-regional control for this cohort of patients. To assess the potential toxicities of radiotherapy delivered using CT-directed treatment in this cohort of patients. 

Participation: Limited to centres with current CPA/FWA # 

Lay Description: The purpose of this study is to find out if it is better or not to receive radiotherapy treatment after chemotherapy. To do this half of the patients in this study will get radiation therapy after chemotherapy and the other half will be watched closely but receive no radiotherapy treatment. This research is being done because we do not know whether radiotherapy treatment is better for this type of breast cancer than no further treatment. 

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Inventory
Hide Tissue Samples
Disease Site Trial Code Patients Accrued Patients - Blocks Patients - Slides Patients - Blocks and/or Slides
BREAST MA25 3 2 1 2
Hide TMA Samples
(Core size is 0.6 mm)
Disease Site Trial Code Patients Accrued TMA Blocks Patients on TMA Blocks
BREAST MA25 3 0 0
Hide Fluid Samples
Disease Site Trial Code Patients Accrued Patients - Whole Blood Patients - Cellular Component of Blood Patients - DNA extracted from Blood Patients - RNA extracted from Blood Patients - Plasma Patients - Serum Patients - Urine Patients - Buccal
BREAST MA25 3 0 0 0 0 0 0 0 0