Status: Closed
Activation Date: 2009APR29
Closing Date: 2014JUN20
Phase: III
Description: A Randomised Phase III Study Of Radiation Doses And Fractionation Schedules For Ductal Carcinoma In Situ (DCIS) Of The Breast
Eligibility: Women with DCIS, radial margins >1 mm post-breast conserving therapy.
Objective: Time of local recurrence Overall survival; disease-free survival; cosmetic outcome, acute and late toxicity; correlative studies.
Participation: Open to member centres
Lay Description: Radiation treatment after surgery to remove the part of the breast that has DCIS within it improves the chances of not developing further cancer in that breast. For women who are considered to be at risk of recurrence in the breast after surgery, the standard treatment is radiation. This research project is testing whether improvements can be made to the radiation treatment.
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Hide Tissue Samples
| Disease Site | Trial Code | Patients Accrued | Patients - Blocks | Patients - Slides | Patients - Blocks and/or Slides |
| BREAST | MA33 | 300 | 184 | 292 | 293 |
(Core size is 0.6 mm)
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Fluid Samples| Disease Site | Trial Code | Patients Accrued | TMA Blocks | Patients on TMA Blocks |
| BREAST | MA33 | 300 | 1 | 9 |
| Disease Site | Trial Code | Patients Accrued | Patients - Whole Blood | Patients - Cellular Component of Blood | Patients - DNA extracted from Blood | Patients - RNA extracted from Blood | Patients - Plasma | Patients - Serum | Patients - Urine | Patients - Buccal |
| BREAST | MA33 | 300 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |